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一种针对肠出血性大肠杆菌O157特异性治疗候选药物介绍

成果领域: 精准医疗

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成果归属企业: 吉林大学动物医学学院邓旭明教授科研团队

成果鉴定时间:

成果介绍

本项目基于肠出血性大肠杆菌(O157)致病过程的关键毒素(志贺毒素Stx2)蛋白表型功能建立抑制剂筛选平台，发现中药成分HH014可显著降低Stx2的生物学活性，有效抑制细菌介导的细胞毒作用。建立O157大肠杆菌感染小鼠模型，发现无药物治疗组小鼠100%死亡；治疗组死亡率显著降低，保护率为80%；可有效恢复感染小鼠肾脏功能性指标(肌酎和尿素氮)和缓解器官炎性反应及病理性损伤。研究成果相继发表于领域内知名期刊J Biol Chem. 、Antimicrob Agents Chemother.和Front Microbiol.上；部分成果被美国化学学会(ACS )旗下Chem. Res. Toxicol以 Spotlight 的形式进行报道和评价。

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000012s ]
[ CACHE ] INIT File
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[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000024s ]
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[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000028s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000014s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000030s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000258s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000013s ]
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[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000698s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000114s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000017s ]
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[ DB ] INIT mysql
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[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000036s ]

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