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培美曲塞鞘内化疗用于恶性肿瘤脑膜转移治疗的临床应用

成果领域: 精准医疗

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成果鉴定时间:

成果介绍

培美曲塞二钠是一种抗叶酸合成抗肿瘤药。研究发现其对胸膜间皮瘤、乳腺癌、非小细胞肺癌具有良好的疗效及安全性。自2017年，我们在国际上首次进行了2项培美曲塞鞘内化疗的前瞻性临床研究，探索了其耐受性，安全性，给药方案，以及临床反应性。研究显示，培美曲塞鞘注化疗的单次给药10mg，每周1-2次给药，对于实体瘤脑膜转移患者具有良好的耐受性，安全性以及治疗反应性。培美曲塞在脑脊液中显示出良好的抗肿瘤活性，无明显蓄积性。研究确定了培美曲塞鞘注给药的推荐剂量及给药方案，使之成为第六种可以用于人类鞘注给药的化疗药物，也是我国发现的首个适合鞘内给药的化疗药物。

成果应用案例介绍

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