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高摄取量脑靶向O-去甲基文拉法辛前体药物的研究与开发

成果领域: 精准医疗

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成果归属企业: 吉林大学生命科学学院顾景凯教授科研团队

成果鉴定时间:

成果介绍

抗抑郁是中枢疾病治疗领域最为关注的问题。基于抗抑郁药O-去甲基文拉法辛（ODV）脑摄取不足的缺陷，项目团队对其进行了结构设计与优化，开发了ODV酚酯类前体药物。该前体药物口服吸收良好、入血后快速透过血脑屏障，在脑组织代谢转化为母体药物ODV发挥作用，药效学研究其抗抑郁效果可与ODV媲美，但给药剂量大为降低，临床应用前景广阔，未来可期。

成果应用案例介绍

联系方式

电话/微信: 13822630888

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基本文件流程错误 SQL 调试

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000011s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001271s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000028s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000261s ]
[ BEHAVIOR ] Run \addons\qrcode\Qrcode @app_init [ RunTime:0.000177s ]
[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000028s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000014s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000029s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000246s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000012s ]
[ ROUTE ] array ( 'type' => 'module', 'module' => array ( 0 => 'index', 1 => 'results', 2 => 'views', ), )
[ HEADER ] array ( 'connection' => 'keep-alive', 'cache-control' => 'max-age=0', 'x-forwarded-for' => '10.3.3.187', 'via' => '1.1 squid-proxy-5b5d847c96-f6lwq (squid/6.13)', 'host' => 'www.zqqyzhfw.com', 'accept-encoding' => 'gzip, br, zstd, deflate', 'user-agent' => 'Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)', 'accept' => '*/*', 'content-type' => '', 'content-length' => '', )
[ PARAM ] array ( 'ids' => '4405', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000691s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000114s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000017s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @upload_config_init [ RunTime:0.000395s ]
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[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000023s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000026s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000032s ]

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