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热休克转录因子1在调控15kDa硒蛋白表达中的应用

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成果归属企业: 深圳大学

成果鉴定时间:

成果介绍

本发明公开一种多靶点Aβ寡聚化抑制剂，所述多靶点Aβ寡聚化抑制剂的结构通式如下：其中，R1是氢、直链状烷基、支链状烷基、烷氧基、卤素中的一种；R2是氢、直链状烷基、支链状烷基、烷氧基、卤素、苯环、六元杂芳环、五元杂芳环、七元芳环、萘、蒽、萘醌、多芳环体系及其取代物中的一种；R3是氢、直链状烷基、支链状烷基、卤素、羧基、硝基、磺酸基、胺基、磷酸基及其取代物中的一种；n＝1～5。本发明所提供的多靶点Aβ寡聚化抑制剂是基于Aβ寡聚过程特征、天然药效团和其他关键酶活性中心结构设计的，结构新颖、活性显著，其对Aβ寡聚化抑制效果佳，水溶性较好，在跨膜性能、活性等方面都具有较好的表现。

成果应用案例介绍

医药医疗>抑制剂>低聚抑制剂

联系方式

电话/微信: 13822630888

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基本文件流程错误 SQL 调试

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000013s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001270s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000038s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000267s ]
[ BEHAVIOR ] Run \addons\qrcode\Qrcode @app_init [ RunTime:0.000184s ]
[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000029s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000015s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000229s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000011s ]
[ ROUTE ] array ( 'type' => 'module', 'module' => array ( 0 => 'index', 1 => 'results', 2 => 'views', ), )
[ HEADER ] array ( 'connection' => 'keep-alive', 'cache-control' => 'max-age=0', 'x-forwarded-for' => '10.1.158.27', 'via' => '1.1 squid-proxy-5b96dc6d46-mbwk5 (squid/6.13)', 'host' => 'www.zqqyzhfw.com', 'accept-encoding' => 'gzip, br, zstd, deflate', 'user-agent' => 'Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)', 'accept' => '*/*', 'content-type' => '', 'content-length' => '', )
[ PARAM ] array ( 'ids' => '4977', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000688s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000113s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000023s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @upload_config_init [ RunTime:0.000378s ]
[ BEHAVIOR ] Run \addons\editpage\Editpage @config_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000023s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000049s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000050s ]

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