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基于可感染病毒颗粒型抗体重链库/轻链库的抗体筛选和制备方法

成果领域:

推广方式:

成果归属企业: 深圳大学

成果鉴定时间:

成果介绍

本发明公开了一种钠肽，该钠肽由脑钠肽和蛇钠肽连接组成；脑钠肽位于钠肽的N端，且蛇钠肽位于钠肽的C端；其中，脑钠肽包括由两个半胱氨酸残基形成的二硫键环状结构。其制备方法包括：获取脑钠肽基因和蛇钠肽基因，通过PCR方法拼接合成钠肽基因；构建包括钠肽基因的表达质粒；将表达质粒转化至适宜表达菌株中进行诱导培养，诱导钠肽的表达。本发明的钠肽同时具有脑钠肽及蛇钠肽的特性，特异性作用显著增强，药物半衰期明显延长；本发明的制备方法工艺简单、切实可行；具有钠肽的基因工程药物可有效作用心脏、血管及肾脏等效应器官，并有效保护上述器官的功能、预防和治疗心脏及肾脏衰竭等疾病。

成果应用案例介绍

化学品>肽类>重组钠尿肽; 医药医疗>药物>药物; 方法过程>制备方法>制备; 疾病>其它疾病>心血管疾病; 疾病>其它疾病>肾脏疾病

联系方式

电话/微信: 13822630888

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邮箱：zeccea@qq.com QQ群：318441538 客服电话：0758-2721389 秘书处电话/微信：13822630888

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[ CACHE ] INIT File
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