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一种协同青霉素及头孢类药物抗MRSA感染候选药物

成果领域: 现代农业

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成果归属企业: 吉林大学汽车动物医学学院邓旭明教授科研团队

成果鉴定时间:

成果介绍

本项目以耐甲氧西林金黄色葡萄球菌（MRSA）的耐药机制的关键耐药酶（β-内酰胺酶）表型功能为基础，建立多种耐药酶的抑制剂筛选平台。发现天然化合物QD3088可有效恢青霉素及头孢类药物等β-内酰胺类抗生素对不同来源MRSA的敏感性中，QD3088联合青霉素及头孢类药物可有效提高MRSA感染肺炎模型小鼠存活率（保护率为90%），可同时抑制MRSAβ-内酰胺酶和溶血素等毒力因子活性，协同青霉素及头孢类药物等抗生素呈现有效的抗MRSA感染作用，效果明显优于舒巴坦和克拉维酸等临床应用的β-内酰胺酶抑制剂。

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000012s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001301s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000027s ]
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[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000031s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000014s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000030s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000234s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000013s ]
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[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000692s ]
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[ DB ] INIT mysql
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[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
[ VIEW ] /www/wwwroot/open.juabc.com/public/../application/index/view/results/views.html [ array ( 0 => 'user', 1 => 'site', 2 => 'config', 3 => 'data', 4 => 'active', 5 => 'login', 6 => 'catelist', 7 => 'views', ) ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000035s ]

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