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嵌合布鲁菌BCSP31病毒样颗粒新型疫苗

成果领域: 现代农业

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成果归属企业: 吉林大学汽车动物医学学院丁壮教授科研团队

成果鉴定时间:

成果介绍

本项目以布鲁菌高保守、高免疫原性的外膜结构蛋白BCSP31为靶点，釆用昆虫杆状病毒表达系统，借助本团队研发的新城疫病毒样颗粒(NDV VLPs)载体平台，构建了嵌合布鲁菌BCSP31病毒样颗粒(BCSP31-cVLPs)新型疫苗，并进一步评价了 BCSP31-cVLPs疫苗的免疫原性及临床保护效力。小鼠模型表明BCSP31-cVLPs疫苗能有效活化树突状细胞，刺激机体产生与商品疫苗株M5相当的体液免疫和细胞免疫应答，并可提供与疫苗株M5同等的免疫保护效力。与现有减毒活疫苗相比，嵌合布鲁菌 BCSP31病毒样颗粒新型疫苗具有绿色、安全、高效的优势，适用于各年龄段羊、猪、牛等动物。

成果应用案例介绍

联系方式

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[ CACHE ] INIT File
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